An intrinsic cardiac adrenergic system can regulate cardiac development and function.

An intrinsic cardiac adrenergic system can regulate cardiac development and function.

Role of Cardiac Output and Adrenergic Function

To investigate hemodynamic and neurohumoral factors as a basis for glucose intolerance in cardiac patients without ischemic heart disease, intravenous glucose tolerance tests were performed on 70 patients aged 14 to 69 years. The mean glucose fractional disappearance rate (Gk) for 41 patients less than age 50 was 1.19 0.07% fall in glucose/min, while in 19 normal subjects, it was 1.60 + 0.14, P...

TBX5 drives Scn5a expression to regulate cardiac conduction system function.

Cardiac conduction system (CCS) disease, which results in disrupted conduction and impaired cardiac rhythm, is common with significant morbidity and mortality. Current treatment options are limited, and rational efforts to develop cell-based and regenerative therapies require knowledge of the molecular networks that establish and maintain CCS function. Recent genome-wide association studies (GW...

Generating mouse models for studying the function and fate of intrinsic cardiac adrenergic cells.

Embryos lacking the ability to synthesize epinephrine and norepinephrine die (probably due to cardiac failure) without exogenous supplementation while mutant neonates can grow into fertile adults without supplementation. These experiments define a critical period during embryogenesis, when norepinephrine and/or epinephrine are essential for mouse development. The critical period is prior to sym...

MiRNA-1/133a Clusters Regulate Adrenergic Control of Cardiac Repolarization

The electrical properties of the heart are primarily determined by the activity of ion channels and the activity of these molecules is permanently modulated and adjusted to the physiological needs by adrenergic signaling. miRNAs are known to control the expression of many proteins and to fulfill distinct functions in the mammalian heart, though the in vivo effects of miRNAs on the electrical ac...